Cmaxid 750mg

INDICATIONS

Used as an alternative drug for infections due to susceptible organisms such as in otitis media, orbital cellulitis, urinary tract, skin and soft tissue, bone and joint infections and surgical infection prophylaxis.

DOSAGE AND ADMINISTRATION

Cefuroxime sodium may be given by deep intramuscular injection, or by slow intravenous injection over 3 to 5 minutes, or by intermittent or continuous intravenous infusion. Continuous intravenous infusion over 30 to 60 minutes.

No more than 750 mg should be injected at one intramuscular site.

General Recommendations

Adult and Adolescent

For most infections 750 mg three times a day. For more severe infections, doses may be increased to 1.5 g three times a day.

If necessary, the frequency of administration of Cefuroxime can be increased to four times a day up to total daily doses of 3 g to 6 g.

Children from 1 month of age:

20 mg/kg (to maximum dose of 750 mg) every 8 hours; this dose may be increased to 50 to 60 mg/kg (to a maximum dose of 1.5 g) every 6 or 8 hours in severe infection and cystic fibrosis.

For surgical prophylaxis, may be given a dose of 50 mg/kg (to a maximum dose of 1.5 g) intravenously before the procedure; this may be supplemented by up to 3 further doses of 30 mg/kg (to a maximum dose of 750 mg) intramuscularly or intravenously at 8-hour intervals for

high-risks procedures.

Neonates under 7 days of age: 25 mg/kg every 12 hours

Neonates under 7 to 21 days of age: 25 mg/kg every 8 hours

Neonates under 21 to 28 days of age: 25 mg/kg every 6 hours

These doses may be doubled in neonates with severe infections but should be given intravenously.

Other Recommendations

Meningitis: hovid Cefuroxime Injection 750 mg is suitable for sole therapy of bacterial meningitis due to sensitive strains. hovid Cefuroxime Injection 0.75 g is given intravenously in doses of 3 g every 8 hours.

Gonorrhea: 1.5 g should be given as a single dose. This may be given as 2 x 750 mg injections into different sites e.g. each buttock.

Surgical infection prophylaxis: The usual dose is 1.5 g (I.V.) with induction of anesthesia for abdominal, pelvic and orthopedic operations, but may be supplemented with two 750 mg (I.M.) doses every 8 hours for up to 24 to 48 hours depending upon procedure.

In total joint replacement, 1.5 g cefuroxime powder may be mixed dry with each pack of methyl methacrylate cement polymer before

adding the liquid monomer.

Patients with renal function impairment may require a reduction in dose or frequency of dosing.

750 mg twice daily; For low-flux hemofiltration the dosage recommended under impaired renal function.

Sequential therapy:

Pneumonia: 1.5 g twice daily (I.V.) for 48-72 hours, followed by 500 mg twice daily Cefuroxime axetil tablet oral therapy for 7 days.

Acute exacerbations of chronic bronchitis: 750 mg twice daily (I.V. or I.M.) for 48-72 hours, followed by 500 mg twice daily Cefuroxime axetil tablet oral therapy for 5-7 days.

Duration of both parenteral and oral therapy is determined by the severity of the infection and the clinical status of the patient.

PREPARATION AND DIRECTION FOR USE

I.M. (Intramuscular) administration constitution:

Vial Dosage Size Amount of Sterile Water for Injection to be Added

750 mg 3.0 mL

I.V. (Intravenous) administration constitution as below:

Vial Dosage Size Amount of Sterile Water for Injection to be Added

750 mg 6.0 mL

The resulting solution should be further diluted in 50 mL to 100 mL of suitable diluents and administered over a period of 30 minutes.

Note: The information given here is limited. For further information, kindly consult your doctor or pharmacist.

Caution: Foods, Drugs, Devices and Cosmetics Act prohibits dispensing without prescription.